443797-96-4 JNJ-7706621 AKSci SYN1048
 
 
Loading Please Wait...
  SYN1048    
JNJ-7706621, 98%
 
4-(5-amino-1-(2,6-difluorobenzoyl)-1H-1,2,4-triazol-3-ylamino)benzenesulfonamide
IDENTITY
CAS Number:443797-96-4
MDL Number:MFCD11100270
MF:C15H12F2N6O3S
MW:394.36
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:98%
Physical Form (at 20°C):Solid
Melting Point:149-155℃°C
Long-Term Storage:Store long-term at 2-8°C
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Solubility:DMSO 79mg/mL, Ethanol 1mg/mL
Application(s):Aurora A - CDK7 - CDK5 - CDK4 - CDK2

REVIEW
 JNJ-7706621 is a dual inhibitor of cyclin-dependent kinases (CDK) and Aurora kinases. It demonstrates highest potency on CDK1/2 with IC50 values of 9 nM and 4 nM respectively. It shows more than 6-fold selectivity for CDK1/2 over CDK3/4/6.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501

Current as of April 29, 2024


Download SDS Request COA

All products are stocked and shipped from San Francisco Bay Area, California, USA.

⚠️
All products are for research and development use only, not for any other uses, and must be handled by technically-qualified persons.

These products are explicitly not intended to be used in foods and/or cosmetics and/or drugs (human and veterinary) and/or consumer products and/or biocides and/or pesticides of any kind unless explicitly stated otherwise.

Products are not sold to individuals. We do not ship to residential addresses. Consumer orders will be cancelled without notice.

New customers undergo an internal onboarding process. As part of this process, new customers may be asked for more information. Additional restrictions may apply.



PubChem